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In this study, seven-layer nanofiber structures consisting of polycaprolactone/ chitosan polymers loaded with methotrexate and 5-fluorouracil anti-cancer drugs, for controlled drug delivery, were produced and evaluated. For this purpose, the second, fourth and sixth layers were loaded with drug and placed between the drug-free layers. The surface morphology of * :يكينورتكلا تسپ ،تابتاكم لوئسم : pa.soltani@cc.iut.ac.ir D ow nl oa de d fr om ja m e. iu t.a c. ir at 0 :3 1 IR S T o n S un da y M ar ch 1 5t h 20 20

Investigating the Release of Methotrexate and 5-Fluorouracil Anticancer Drugs from Multi-Layered Nanofiber Structure of Polycaprolactone/Chitosan