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espanolFundamento y objetivos: Los estudios sobre validacion del FRAX® en Espana muestran una infravaloracion del riesgo de fracturas osteoporoticas principales (FOP) y predicciones mas ajustadas para las fracturas femorales (FF). Se ha sugerido que este algoritmo podria mejorarse con datos mas concretos de la epidemiologia de las fracturas en Espana. Los objetivos de este trabajo fueron describir el riesgo basal de fracturas segun el modelo espanol FRAX® en las participantes de la cohorte FRODOS y comparar estos datos con la aplicacion de otros modelos europeos FRAX® en la misma cohorte. Metodos: Estudio observacional en una cohorte poblacional de 2.968 mujeres postmenopausicas (59-70 anos); se utilizo la version online desktop de FRAX® para multiples entradas de datos para calcular los riesgos de FOP y FF a 10 anos aplicando los modelos espanol, frances, ingles y sueco en la misma cohorte. Resultados: El riesgo mas bajo correspondio al modelo espanol: FF: 1,22% (36 fracturas esperadas) y FOP: 5,28% (n=197), mientras que el riesgo mas alto fue el del modelo sueco: FF: 3,15% y FOP 13,51% (n=401). Los modelos de Francia y el Reino Unido presentaron valores intermedios. Conclusion: En una cohorte espanola de 2.968 mujeres postmenopausicas el riesgo porcentual de fracturas esperadas a 10 anos se incrementa con un gradiente de latitud sur-norte al aplicar diferentes modelos FRAX® europeos. Los resultados de incidencia de fracturas en la cohorte FRODOS previsto para los proximos anos, confirmaran o no la utilidad del presente analisis. EnglishBackground and objectives: Studies on the validation of FRAX® in Spain show an underestimation of the risk of principal osteoporotic fractures (POFs) and more accurate predictions for femoral fractures (FF). It has been suggested that this algorithm may be improved with more specific data on the epidemiology of these fractures in Spain. The objectives of this work were to describe the baseline risk of fractures according to the Spanish FRAX® model in the participants of the FRODOS cohort, and to compare these data with the application of other European models of FRAX® in the same cohort. Methods: Observational study in a population cohort of 2,968 postmenopausal women (59-70 years of age). The online desktop version of FRAX® was used for multiple data entries to calculate the risk of POFs and FFs at 10 years using the Spanish, French, British and Swedish models in the same cohort. Results: The lowest risk corresponded to the Spanish model: FF: 1.22% (36 expected fractures) and POF: 5.28% (n=197), while the highest risk was for the Swedish model: FF: 3.15% and POF 13.51% (n=401). The models for France and the United Kingdom had intermediate values. Conclusion: In a Spanish cohort of 2,968 postmenopausal women the percentage risk of expected fractures at 10 years increased following a south-north latitude gradient when different European FRAX® models were applied. The results for the incidence of fractures on the FRODOS cohort predicted for the coming years will confirm, or not, the usefulness of this analysis.

Riesgo de fractura en la cohorte FRODOS: estudio comparativo de la aplicación del modelo FRAX® español, francés, inglés y sueco