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Purpose: To investigate the distribution of methionine synthase A2756G ( MSA2756G ) in the hypertensive patients in northwest Chinese population. Methods: A total of 378 unrelated hypertensive patients attending Ningxia Peoples Hospital, Ningxia Province, China, were recruited for this study. We analyzed genotype by amplication - created restriction sites (ACRS) and polymerase chain reaction - restrict fragment length polymorphism (PCR - RFLP) in hypertensive patients, and inspected the relation of the genotype with hypertension by χ2 and t test. Results: The frequency of G allele was 10.25 % in the control group and 14.04 % in hypertension group; it was not statistically different ( p > 0.05). In the male group, the frequency of allele G was 11.50 % in control group, and 8.79 % in hypertension group. There was no significant difference between control and hypertension groups ( p > 0.05). In the female group, the frequency of allele G was 9.00 %, in control and 19.54 % in hypertension group ( p < 0.05), while in the hypertension group, allele G was 8.79 % in males which is significantly lower ( p < 0.05) than in females (19.54 %) . Conclusion: Allele G of MSA2756G is a risk factor for hypertension in female in this Chinese population of this study. Keywords: Hypertension, Methionine synthase, Polymorphism, Gender, Amplification-created restriction sites, Allele G, MSA2756G

Gender-specific association of <i>MSA2756G</i> with hypertension in patients attending a health facility in Ningxia Province, China