English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The quality and toxicity assessment of foot and mouth disease virus vaccine was carried out in inoculated guinea pigs. The vaccine was developed from local isolates for the control and prevention of foot and mouth disease in Nigerian cattle. All the vaccine inputs tested were sterile and the high mean titre levels of complement fixing antibodies (92.8 and 147.2) and serum neutralizing antibodies (1.68 and 2.15), either as single dose or repeated doses inoculations. The blood immune cells parameters showed a positive immunological response due to activation by the vaccine antigens. There were increases in their population as compared to the controls. The blood enzyme profiles did not show any significant evidence of tissue or organ damage as all the results obtained were within the reference standard ranges of normal healthy guinea pigs. The findings from the study show that the vaccine could be used for the control and prevention of foot and mouth disease in Nigerian livestock. Keyword : Foot and Mouth Disease, Antibody, Quality, Toxicity, Vaccine.

Quality and Toxicity Assessments of Foot and Mouth Disease Virus Vaccine in Inoculated Guinea Pigs