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Objectif: L’objectif de cette etude a ete d’apporter une base scientifique a l’utilisation traditionnelle de  Zanthoxylum zanthoxyloides , plante usuellement employee dans la pharmacopee africaine. S’est agi d’examiner les mecanismes d’action des principes actifs de cette plante sur le coeur isole de rat et sur l’aorte isolee de cobaye. Methodologie et Resultats: Les dispositifs d’enregistrement de l’activite mecanique du coeur isole de rat et de l’activite contractile de l’aorte isole de cobaye nous ont permis de mener a bien ces experimentations. On a pu observer que sur le coeur isole, l’extrait aqueux de Zanthoxylum zanthoxyloides de 10 -8 a 10 -5 mg/ml, induit des effets chronotrope et inotrope positifs, et aux concentrations comprises entre 10 -4 a 10 -2  mg/ml, entraine des effets chronotrope et inotrope negatifs. Sur l’aorte isolee, l’extrait provoque une vasorelaxation endothelium-dependante entre 10 -8 et 10 -2 mg/ml. Ces effets sur le coeur isole sont inhibes par le propranolol et par l’atropine. Conclusion et Application: La caracterisation pharmacologique des principes actifs contenus dans l’extrait aqueux de Zanthoxylum zanthoxyloides , au moyen de l’atropine et du propranolol, a revele la presence concomitante dans cet extrait de substances cholinomimetiques qui seraient responsables des effets chronotrope et inotrope negatifs et de substances adrenomimetiques responsables quant a elles des effets chronotrope et inotrope positifs sur le coeur isole de rat. Apres l’etude de l’extrait brut, il convient de realiser le fractionnement de cet extrait, afin de caracteriser plus finement les fractions les plus actives. L’etude de ces fractions permettra de mieux caracteriser les principes actifs de cette plante. Mots cles: Zanthoxylum zanthoxyloides , cholinomimetiques, adrenomimetiques, vasorelaxation English Abstract Objective: The objective of this study was to provide a scientific basis for the traditional use of Zanthoxylum zanthoxyloides , commonly used plant in the African pharmacopoeia. It is to examine the mechanisms of action of the active components of this plant on the isolated rat heart and to the isolated aorta of guinea pig. Methodology and Results: The recording devices for the mechanical activity of isolated heart of rat and contractile activity of isolated guinea pig aorta enabled us to carry out our experiments. It has been observed that on the isolated heart aqueous extract of Zanthoxylum zanthoxyloides of 10 -8 to 10 -5 mg / ml, induced chronotropic and inotropic of positive effects, and the concentrations between 10 -4 to 10 -2 mg / ml causes chronotropic and inotropic negative effects. On the isolated aorta, the extract causes endotheliumdependent vasorelaxation between 10 -8 and 10 -2 mg / ml. These effects on the isolated heart are inhibited by propranolol and atropine Conclusion and Application: Pharmacological characterization of active components contained in the aqueous extract of Zanthoxylum zanthoxyloides , using atropine and propranolol, revealed the concomitant presence in this extract from cholinomimetic substances that are responsible for the negative inotropic and chronotropic effects and adrenomimetics substances responsible for their inotropic and chronotropic positive effects on isolated rat heart. After the study of the crude extract, it is necessary to realize the fractionation of this extract to characterize more precisely the most active fractions. The study of these fractions will better characterize the active ingredients of this plant. Keywords: Zanthoxylum zanthoxyloides , cholinomimetics, adrenomimetics, vasorelaxation

journal of applied biosciences

Étude des effets pharmacologiques d’un extrait aqueux de &lt;i&gt;zanthoxylum zanthoxyloïdes&lt;/i&gt; (Lam.) waterman, 1981 (Rutaceae) sur le coeur isole de rat et l’aorte isolée de cobaye