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The ethanolic leaf extract of Setaria megaphylla (100-300 mg/kg) was investigated for pharmacological properties against egg white albumin - induced inflammation, Chemical as well as thermal- induced pain. The extract demonstrated a dose – dependent anti- inflammatory and antinociceptive activities. These activities were comparable to that of ASA (100mg/kg). The leaf extract possess anti inflammatory and analgesic properties, which can be exploited in health care (Afr. J. Biomed. Res. 9: 229 – 233) Keywords: Setaria megaphylla , anti inflammatory, analgesic.

Anti-inflammatory and anti-nociceptive effects of ethanolic extract of Setaria megaphylla leaves in rodents