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Tzanck smear is a cytological examination currently used in the diagnosis of vesiculobullous diseases and, slit-skin smear (SSS) is used to diagnose plaque and nodular lesions such as cutaneous leishmaniasis, mastocytosis and tumors. Fine-needle aspiration cytology (FNAC) is also used for many oncological indications including simple hyperplasia, benign neoplasms and cancers. A 42-year-old woman was admitted with the complaints of red nodules, which she noticed on her breast about 10 days ago, and back pain. Approximately 8 months ago, a metastasized lymphadenopathy, triple-negative breast carcinoma was diagnosed and chemotherapy was given before subcutaneous mastectomy and silicone implant surgery. One month later, she was referred by the oncology clinic for zosteriform painful lesions on the breast found during radiotherapy. A dermatologic examination showed peau d’orange appearance of the left breast with zosteriform pink-red nodules about 3-4 mm in diameter (Figure 1). Patient consent form for photos were taken. Multinucleated giant cells were not observed whereas tumor cells with narrow cytoplasm and large hypochromatic nuclei were observed on SSS specimens obtained from a nodular skin lesion (Figure 2a). Histopathologic examination revealed solid infiltration of cystic, cribriform and adenoid structures extending from the papillary dermis to the depths of the reticular dermis (Figure 2b). Based on the clinical and immunohistochemical findings (e.g., estrogen receptor, progesterone receptor, GATA positivity), skin metastasis of breast carcinoma was diagnosed. Anahtar Kelimeler: Tzank yayma, zona, meme kanseri

Cytodiagnosis of zosteriform cutaneous metastases from breast cancer with Tzanck smear: Report of a case with histopathological correlation