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A 57-year-old male with history of thalassemia intermedia and hepatocellular carcinoma underwent a positron emission tomography/computed tomography (PET/CT) scan with 18 F-choline before radioembolization procedure with 90 Y-microspheres. The PET/CT scan with 18 F-choline demonstrated highly increased tracer incorporation within a gross lesion in the hepatic dome coupled with diffuse activity in bone marrow, this latter aspect was probably due to the compensatory hematopoiesis stimulation induced by chronic hemolysis. This pattern of skeletal 18 F-choline uptake should be considered as a peculiar PET/CT finding in thalassemic patients.

Increased Bone Marrow <sup>18</sup>F-Choline Uptake in a Patient with Hepatocellular Carcinoma and Thalassemia Intermedia