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In this retrospective study on a large GH deficient pediatric population, conventional use of replacement therapy resulted in an increase in HbA1c and insulin resistance after one year of therapy, regardless of rhGH dosage. These alterations were transient and not associated with significant changes in glucose metabolism during the subsequent follow-up.

Glucose Metabolism Evaluated By Glycated Hemoglobin And Insulin Sensitivity Indexes In Children Treated With Recombinant Human Growth Hormone