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In a rat model, if with the ultrasonographic guidance, BoTA is injected to the muscle which perforator of the prospective SPPP flap originated and flap surgery is performed one month later after this injection, the perfusion of SPPP flap increases scintigraphically and this improves flap survival and reduces its necrosis.

Effect of Botulinum toxin-A Injected to Muscle Tissue on Perfusion and Survival of Fasciocutaneous Single Perforator-pedicled Propeller Flap in Rats