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Copyright: © 2016 Gupta P. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. P-glycoprotein (P-gp) is a transmembrane permeability glycoprotein belonging to the ATP binding cassette (ABC) super family that functions specifically as a carrier mediated primary active efflux transporter. It is widely distributed throughout the body and has a diverse range of substrates that include several vital therapeutic agents whose bioavailability is reduced or resistance is induced because of the protein efflux. P-gp was first discovered in 1976 for its role in multi-drug resistance in cancer; it is over expressed in several human tumors and is an important barrier to success in cancer treatment. Due to its role in drug metabolism, P-gp has considerable clinical relevance as it affects the absorption, distribution and secretion of anticancer drugs [1]. Several natural products from plants and marine sources have been reported for their P-gp inhibitory action and thereby serving as potential chemopreventives when co-administered with anti-cancer agents. The P-gp inhibitory compounds from plant sources belong to various categories such as flavonoids, stilbenes, coumarins, terpenoids, alkaloids and saponins whereas the P-gp inhibitors from marine natural products belong to the class of polyketides.

P-Glycoprotein Inhibitors from Natural Sources as Chemopreventives