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In biological systems, the genomic approach has emerged to provide a better understanding of the pathophysiological conditions leading to pregnancy-associated disorders and complications, thereby providing a perspective for improving prenatal development outcomes. Nevertheless, it is insufficient to accurately predict protein expression patterns and functions from quantitative messenger RNA [mRNA] due to post-transcriptional regulation mechanisms [mRNA export, surveillance, silencing and turnover] and post-translational modifications which can determine protein activity, localization, turnover and interactions with other proteins [1]. Therefore, investigations of steady-state mRNA expression can only partially predict protein abundances in mammalian cells [2]. In fact, mRNAs are less stable than proteins [3]. In addition, mRNAs are produced at a much lower rate than proteins [4].

Proteomics and Biological Systems: Application in Oxidative Stress, Nutrition and Prenatal Development