English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

International audienceOsteoinductive and antiosteroporotic phenomena could be created by using synthetic biomaterials for applications in bone surgery. In the present study, CH-based bioactive glass (BG-CH) with 17 wt% chitosan was elaborated by a freeze-drying process. BG-CH was implanted in the muscle and in the femoral condyles of ovariectomized rats. Grafted tissues were carefully removed for physico-chem. and histol. anal. Several physic-chem. techniques (XRD, FT-IR, MEB, ICP-OES and NMR) were employed to highlight the effects of chitosan on the glass matrix before and after implantation. The results of the study show that despite the non-addnl. osteogenic cells or agents, BG-CH is endowed with an osteoinductive property. After 8 wk, 13C NMR spectra showed the characteristic signals of γ-carbons of the hydroxyproline (71 ppm) abundant in collagen. γ-carboxyglutamate (55 ppm), which occurs in several other bone proteins like osteocalcin, indicating the BG-CH degrdn. and the dominance of the bone tissue formation. Moreover, this study showed a rise in Ca and P ion concns. in the implanted microenvironment, leading to the formation/deposition of Ca-P phases. Trace elements such as Zn and Fe were detected in the newly-formed bone and involved in the bone healing. The study highlights the suitability and the extensive applications of BG-CH composites and the clin. useful therapy in regenerative medicine

Osteoinduction and Antiosteoporotic Performance of Hybrid Biomaterial Chitosan-Bioactive Glass Graft: Effects on Bone Remodeling