Open AccessHypoglycemic Effect due to Insulin Stimulation with Plantago major in Wistar Rats
Author(s) -
María Abud,
Andrea Nardello,
Jeronimo Facundo Torti
Publication year - 2017
Publication title -
medicinal and aromatic plants
Language(s) - English
Resource type - Journals
ISSN - 2167-0412
DOI - 10.4172/2167-0412.1000292
Subject(s) - medicine , diabetes mellitus , alloxan , glibenclamide , insulin , endocrinology , intraperitoneal injection , pancreas , glucose tolerance test , pharmacology , insulin resistance
Diabetes mellitus (DM) refers to a group of common metabolic disorders that share the phenotype of hyperglycemia, which causes secondary pathophysiological changes in multiple organ systems. Several times the Plantaginaceae family have been reported as crude drugs with hypoglycemic effect mainly attributed to their high fiber content [5]. Objective: The current study was hypothesized to investigate the beneficial effects of methanol extract from the aerial part of Plantago major (Pm) on hyperglycemia-mediated oxidative stress and inflammatory responses Alloxan induced diabetes mellitus, and in normal rats.