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Copyright: © 2012 Kashir J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Human infertility affects approximately 10% of couples worldwide and has led to the development of a suite of clinical laboratory techniques designed to combat such conditions, collectively referred to as ‘Assisted Reproductive Technology’ (ART) [1]. Such methodology has subsequently resulted in the birth of more than 4.6 million babies worldwide. Infertility may arise as a result of individual male or female factors, a combination of both, or for unknown reasons (idiopathic infertility) [2,3]. While clinical and laboratory aspects of ART have been significantly refined since their first successful clinical application, global pregnancy and live birth rates from ART rarely exceed ~40% [3]. Indeed, successful pregnancy and delivery rates from conventional ART techniques such as in vitro fertilisation (IVF) or Intracytoplasmic Sperm Injection (ICSI) may be as low as 22.4% and 23.3% respectively [3]. As the number of couples seeking infertility treatment increases, it is crucial to develop new techniques and protocols to enhance the success of ART [4].

human genetics and embryology :

Clinician-Induced (Iatrogenic) Damage Incurred during Human Fertility Treatment: Detrimental Effects upon Gamete and Embryo Viability and the Potential for Epigenetic Risk