Open AccessPARP1 Differentially Interacts with Promoter region of DUX4 Gene in FSHD Myoblasts
Author(s) -
Vishakha Sharma,
Sachchida Nand Pandey,
Hunain Khawaja,
Kristy J. Brown,
Yetrib Hathout,
Yiwen Chen
Publication year - 2016
Publication title -
journal of genetic syndromes and gene therapy
Language(s) - English
Resource type - Journals
ISSN - 2157-7412
DOI - 10.4172/2157-7412.1000303
Subject(s) - facioscapulohumeral muscular dystrophy , myocyte , microbiology and biotechnology , parp1 , biology , promoter , chemistry , gene , gene expression , polymerase , genetics , poly adp ribose polymerase
The goal of the study is to identity proteins, which interact with the promoter region of double homeobox protein 4 (DUX4) gene known to be causative for the autosomal dominant disorder Facioscapulohumeral Muscular Dystrophy (FSHD).