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The present investigation was carried out on thirty six mature Westar rats from laboratory animal unit in the faculty of veterinary medicine, Zagazig University, Egypt. The animals were divided into six groups of six animals for each. Group I was considered as a control group. Group II was treated with tartrazine only in a dose 500 mg/kg body weight by oral gavage for 30 day. Group III was treated with the same dose of tartrazine with 300 mg/kg body weight Royal jelly. Group IV was treated with tartrazine and Code liver oil in a dose 0.4 mg/kg body weight. While the last two groups, V and VI were treated with Code liver oil and Royal jelly separately by the above mentioned doses for 30 days. At the end of experiment, cervical dislocation of rats and for the histological studies, the liver, kidney, testis and brain tissues in addition to stomach were separated and small pieces from them were taken, fixed in neutral buffered formalin 10%, dehydrated, cleared and processed for paraffin blocks and 5 micron sections were obtained, mounted on a glass slides and stained histologically with Hematoxylin and Eosin (H&E) and Blue Masson’s Trichrome. Groups I, V, VI showed normal histological structure of all selected tissues without any abnormalities. Group II showed severe steatosis, diffuse degeneration, necrosis of hepatic tissues, fibrous tissue proliferation with anti-inflammatory cells infiltration in the portal areas and moderate disorganization of hepatic cords. Furthermore, hyperplasia of the interstitial connective tissue and Leydig cells with marked vacuolations were recognized. Moreover, slightly vacuolations in brain tissues were recognized specially within the white matter as well as degenerative changes in stomach mucosa. And also, hyaline degeneration in renal tubules and vacuolations of glomeruli were observed. The present investigation concluded that the serious effect of tartrazine toxicity was more pronounced in liver then kidney, stomach, testis and brain tissues respectively. Moreover, the curative protective effect of both royal jelly and cod liver oil are non-significant against tartrazine toxicity.

journal of cytology and histology

Histological Changes of Selected Westar Rat Tissues Following the Ingestion of Tartrazine With Special Emphasis on the Protective Effect of Royal Jelly and Cod Liveroil