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Background: Treatment of locally-advanced squamous cell carcinoma of the head and neck (SCCHN) requires multi-disciplinary care often resulting in a prolonged diagnosis to treatment interval (DTI). This study aims to identify factors that influence DTI and to assess the impact of DTI on treatment outcomes. Methods: The medical records of 135 patients with SCCHN who were treated with definitive chemoradiotherapy between 2000 and 2009 at the Clement J Zablocki VA Medical Center were reviewed and analyzed. Results: Median DTI was 44 days. A Cox-Model identified that transfer patients had prolonged DTI. Longer DTI had a significant negative impact on overall survival (RR 1.009, p = 0.0386) but did not impact distant (RR 0.99, p = 0.89) or local control (0.99, p = 0.23). Conclusion: Increased DTI in patients with SCCHN results in a statistically significant negative survival impact. Efforts need to be directed to improving DTI and on expediting and streamlining the care of transfer patients.

journal of cancer science and therapy

Diagnosis to Treatment Interval and Outcome in Patients with Locally-Advanced Squamous Cell Carcinoma of the Head and Neck in a Veterans Affairs Medical Center