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Background: Evaluation and investigation of the pro-oxidant role of the angiotensinogen (AGT) among Tunisian  coronary. Materials and methods: The current study evaluated the frequency of AGT (M235T and A(-6)G) polymorphism  in relation to coronary artery disease in a group of Tunisian population. AGT polymorphism was determined by  Real Time PCR. These subjects (150 patients and 120 controls) beneficed also by an enzymatic determination of  superoxide dismutase (SOD), glutathione peroxidase (GPX), total antioxidant status (TAS), catalase (CAT) activity  was determined spectrophotometrically and serum lipid peroxides were measured by the fluorimetric method reaction  to reveal the atherogenic effects of these radical species and investigate their interactions with AGT polymorphisms. Results: The results revealed that there was a positive risk of developing coronary artery disease when having  the T allele whether in homozygous or heterozygous state. Statistical tests of the baseline correlation between  oxidative stress parameters and M235T genotype groups showed a negative correlation between MM genotype  group and oxidant parameters (SOD, GPX and TAS). The same result was found in TT and MT genotype groups. Conclusion: This study shows that the AGT polymorphisms were associated with the presence of coronary  artery disease. In addition to its vasoconstrictor role, AGT can be considered as a pro-oxidant, these two effects  combine in the genesis and the complications of cardiovascular diseases.

Association Between the Angiotensinogen Gene Polymorphism and The Pro-Oxidant Effect in Tunisian Patients with Coronary Heart Disease