Role of Orexin System in Obesity

Obesity is a public health disease and its incidence is steadily increasing both in adults and in children especially\udin the Western World. It is important to understand the underlying mechanisms of obesity and possible treatments as\udthe orexin system with its receptors, which are involved in different physiological processes. In fact, the aim of this\udmini-review is to consider the importance of the orexin system and the role that orexin plays in the regulation of obesity\udand physical activity. Furthermore to demonstrate how the orexin and its receptors fit within a network distributed\udin multiple brain areas, each with specific actions, whose activation and interconnection has been seen to lead\udto a lower propensity for increase of fat mass, it could thus constitute an important future target for prevention and\udtreatment of obesity