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Human epidermal growth factor receptor 2 (HER2) overexpression is seen in 25% of breast cancers. Patients with HER2-positive breast cancer have aggressive disease and inferior survival. HER2 overexpression is assessed by immunohistochemistry or fluorescent in situ hybridization-based methods. Trastuzumab has shown to improve survival in HER2-positive breast cancer. It is recommended in patients with &gt;T1c for 1-year duration in adjuvant setting, preferably given concurrently with taxane.

Trastuzumab: A Milestone in Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer