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Neuromyelitis optica spectrum disorder (NMOSD) is a chronic inflammatory disorder of the central nervous system that particularly involves the optic nerve and spinal cord. It is pathologically characterized by astrocytopathy, followed by tissue destruction (Fujihara, 2011). Historically, NMOSD has been considered to be an Asian optic-spinal form of multiple sclerosis (MS), as patients with NMOSD were distributed predominantly in Asian rather than in Western countries.

Multiple sclerosis and neuromyelitis optica spectrum disorders: some similarities in two distinct diseases