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Preconditioning stimulus: Preconditioning is an adaptive response, whereby a small dose of a harmful substance protects the brain from a subsequent damaging insult (Dirnagl et al., 2009). The concept of preconditioning was first described in an ischemic heart model, it was observed that brief ischemic episodes protect against a subsequent ischemic insult (Murry et al., 1986). Consequently, several preconditioning treatment paradigms are used in the clinic to protect patients against an ischemic insult in heart pathologies (Jimenez-Mateos et al., 2015). This data shows the importance of understanding the underlying mechanism to preconditioning, and its translation in the clinic in brain disorders. In concordance, any injury to the brain applied below the threshold of cell damage, including seizures, will induce preconditioning and neuroprotection to the brain.

Can we protect the brain via preconditioning? Role of microRNAs in neuroprotection