English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic (DA) neurons and a decrease in striatal dopamine, which is associated with clinical movement disorders including a tremor at rest, rigidity of the limbs, bradykinesia (slowness and paucity of voluntary movement) and postural instability (a tendency to fall even in the absence of weakness or cerebellar balance disturbance) (Kim et al., 2012). Although the lack of fully understanding of the etiology of PD, accumulating evidence suggests that microglial activation (Kim et al., 2010) and insufficient support of neurotrophic factors (Kim et al., 2012; Nam et al., 2014) may be crucial for the initiation and progression of PD. Thus the control of microglial activation and the support of neurotrophic factors may be useful to prevent the degeneration of the nigrostriatal DA projections in the adult brain.

Inhibition of microglial activation and induction of neurotrophic factors by flavonoids: a potential therapeutic strategy against Parkinson′s disease