English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Host genetic factors can influence susceptibility, morbidity and mortality from schistosomiasis. The study explored the association between single nucleotide polymorphisms (SNPs) in interleukin-10 (IL-10) and tumour necrosis factor alpha (TNF-α) promoter regions and susceptibility to  Schistosoma haematobium  infection.    Methods  Urine specimens were collected from 361 primary school children aged 5–15 years from schistosomiasis endemic areas of Manicaland and Mashonaland central provinces.  Schistosoma haematobium  was diagnosed using the urine filtration method. Only 272 participants provided adequate blood for genotyping. Genotyping was performed using the amplification refractory mutation system-polymerase chain reaction. The association between IL-10 and TNF-α SNPs and  S. haematobium  infection was analysed using the chi-square test.    Results   Schistosoma haematobium  infection was confirmed in 26.8% of the participants. No significant difference in  S. haematobium  prevalence between men (51.6% of those infected) and women (48.4%) (χ 2  = 0.008,  df  = 1,  p  = 0.928) was observed. The total IL-10 -1082 G, IL-10 -819 C and TNF-α -308G allele distribution between  S. haematobium  infected and uninfected participants was 50.7% and 51.5% (χ 2  = 0.025,  df  = 1,  p  = 0.87), 54.3% and 60.6% (χ 2  = 1.187,  df  = 1,  p  = 0.187) and 82.1% and 80.9% (χ 2  = 0.099,  df  = 1,  p  = 0.753), respectively, and the differences were not significant.    Conclusion  Interleukin-10 -1082 G/A, IL-10 -819 C/T and TNF-α -308 G/A SNPs were not significantly associated with susceptibility to  S. haematobium  infection. The prevalence of schistosomiasis is still in the moderate range and is similar in boys and girls.

southern african journal of infectious diseases

Interleukin-10 and tumour necrosis factor alpha promoter region polymorphisms and susceptibility to urogenital schistosomiasis in young Zimbabwean children living in Schistosoma haematobium endemic regions