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ABSTRACT N-(3-(1H-Imidazol-1-yl)propyl)-2-phenylquinazolin-4-amine ( 2) was obtained by nucleophilic substitution of 1-(3-aminopropyl)-imidazole over 4-chloro-2-phenylquinazoline ( 1) with DMF/TEA at room temperature. The precursor and product were characterized by NMR spectroscopy. The structure of the title compound was confirmed by X-ray diffraction methods. The quinazoline fragment ( 2) is essentially planar and makes a dihedral angle of 66.35 ° with the imidazole plane. In the crystal packing the molecules are associated by two strong intermolecular NH∙∙∙∙N hydrogen bonds with graph-set motif R 22 (16). These pairs are linked by two π-π interactions. INTRODUCTION Quinazoline derivatives are known to possess remarkable anti-inflammatory activity as NOS-II 1,2 and PDE-4 3 inhibitors, among others. They are also found to show broncho-dilatory 4 and anti-allergic 5 properties. In addition, these compounds also have a therapeutic benefit as an anti-invasive agent with potential for activity in early and advanced solid tumors, metastatic bone disease and leukemias

¹H AND 13C NMR SPECTRAL ASSIGNMENTS AND X-RAY CRYSTALLOGRAPHY OF N-(3-(1H-IMIDAZOL-1-YL)PROPYL)-2-PHENYLQUINAZOLIN-4-AMINE