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Radiotherapy is a source of human exposure to ionizing radiation. This pure energy causes deleterious effects on tissues, which result from oxidative stress, a phenomenon in which there is the participation of the Renin-Angiotensin System ( RAS). The male genital organs are extremely radiosensitive and the action of radiation in the testes can significantly affect spermat ogenesis. In search of potential radioprotective for male genital system, this study investigated whether the AT 1 ec ptor antagonists minimize radiationinduced damage to reproductive tissues, by decreasing oxidative stress. Male Wistar rats were divided into six groups: 0 Gray ( Gy) (control), 5 Gy (single dose in the scrotal area), telmisartan, losartan, 5Gy+telmisartan and 5Gy+losartan. The treatment start ed the day after irradiation with losartan 34 mg/kg (two times/day) and telmisartan 12 mg/kg (one time/day) during 60 days. For ultrastruc t ral analysis, the testis fragments were fixed in 2 % glutaraldehyde and 4 % paraformaldehyde in 0.1 M phosphate buffer, pH 7.3. The material was postfixed for 2 h in 1 % osmium tetroxide. For collagen evaluation, the sections were stained with Picrosirius-red method. Serum testosterone was determined. The date showed the deleterious effects of gamma radiation on testicular ultrastructure. Ric h accumulation of collagen fibers in the interstitium was observed in the irradiated groups, especially the irradiated and nontre te testes. No significant difference was detected in serum testosterone concentration among the studied experimental groups. Treatments wi th telmisartan and losartan influenced the onset of attenuation on ultrastructural damages arising from ionizing radiation. Althou gh the data strongly suggest that AT 1 receptor antagonists may promote radioprotection to the testes, further studies with a longer duration of treatment are required for these potentially positive effects to be maximized and, therefore, to better characterize radioprote ction to reproductive parameters.

international journal of morphology

Potential Radioprotective Effect of AT1 Receptor Antagonists Against Morphological and Ultrastructural Changes in the Testes Induced by Ionizing Radiation