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This investigation was undertaken in order to quantify the effects of early polysensorial enrichment on the development of cortical pyramids, located in the parietal cortex of rats simultaneously submitted to protein-energy undernutrit ion. A short period of stimulation during suckling significantly decreases the cellular density in the cortical plate (phylogenetic-on tog netic evolutionary index). Results suggest that the cerebral cortex develops according to a sophisticated neuronal network, which exh ibits a notable degree of structural specificity, regulated by genetic and environmental clues. The most obvious prediction is that env ironmental influences are probably transduced as a structural expression in the developing parietal cortical plate.

Effects of Preweaning Polysensorial Enrichment upon Development of the Parietal Cortical Plate of Undernourished Rats: A Stereological Study