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Dengue is a major public health problem in tropical countries including Sri Lanka. There are no specific antiviral drugs or an effective vaccine available against dengue as yet. Plant derived compounds are an important option for development of new drugs. Carica papaya of the family Caricaceae is a traditionally used medicinal plant to treat dengue. The objective of this research was to determine the antiviral activity of C. papaya leaf extracts against dengue virus-1 (DENV1). As a first step of exploring the antiviral activity, the cytopathic effects of the C. papaya leaf extract was done to select a minimum toxic concentration against the experimental DENV-1 infection in C6/36 cells.

Antiviral activity of <em>Carica papaya</em> extract against experimental dengue virus 1 infection