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O presente estudo teve por objetivo analisar as características morfoquantitativas de neurônios mioentéricos nitrérgicos do corpo do estômago de ratos diabéticos. O corpo do estômago de 5 ratos normoglicêmicos e de 5 ratos diabéticos foi submetido a preparados de membrana corados pela técnica histoquímica da NADPH-diaforase. Verificaram-se, nos animais diabéticos, diminuição do peso corporal, aumento do consumo diário de água, da glicemia em jejum e da hemoglobina glicada. Com os dados obtidos, não foi observada diferença significativa na densidade de neurônios nitrérgicos entre os dois grupos, porém as áreas dos perfis celulares neuronais dos ratos diabéticos foram significativamente maiores. Constatou-se, portanto, que o diabetes induzido por estreptozootocina não acelera a morte dos neurônios nitrérgicos, contudo aumenta a expressão desses neurônios The aim of this study was to analyze the morphoquantitative features of the nitrergic myenteric neurons from the body of the stomach of diabetic rats. The body of the stomach of five normoglicemic rats and of five diabetic rats were prepared as whole-mounts stained by the histochemical technique of NADPH-diaphorase. Decreased body weight and increased daily ingestion of water, fast glicemia and glycated hemoglobin were verified in diabetic animals. According to the data obtained, significant difference in the density of nitrergic neurons was not observed between the two groups, but the areas of the neuronal cell body profiles in the diabetic rats were significantly larger. Results showed that the streptozotocin that induced diabetes does not accelerate the death of the nitrergic neurons, but increases the expression of these cell

acta scientiarum. biological sciences

Avaliação da população de neurônios mioentéricos NADPH-diaforase positivos do corpo do estômago de ratos com diabetes crônico induzido pela estreptozootocina