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A facile stepwise synthesis of 2,5‐disubstituted 1,3,4‐oxadiazoles proceeding via oxidative cyclization of N‐acylhydrazones is reported. The reaction is efficiently promoted by 2,3‐dichloro‐5,6‐dicyano‐1,4‐ benzoquinone (DDQ) to afford the desired products mostly in high yields and in relatively short times. The final 1,3,4‐oxadiazole derivatives are also synthesized directly from acid hydrazides and aldehydes in a one‐pot procedure. The substrate scope and limitations of the reported transformation are discussed in detail.

Study on DDQ-promoted synthesis of 2,5-disubstituted 1,3,4-oxadiazoles from acid hydrazides and aldehydes