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A facile synthesis of novel monocyclic transand cis-3-oxy/thio/seleno-4-pyrazolylβ lactams (5, 6) is described. The reaction of 2-methoxy/phenoxy/b enzyl/phenylthio/seleno ethanoic acids or acetoxyacetyl chloride 4 with pyrazolyl substituted Schiff ′s bases 3a-d using POCl 3 and Et 3N in refluxing toluene furnished β-lactams ( 5, 6). These synthesized β-lactams have been characterized by spectroscopic techniques viz. NMR (H, C and Se), FT-IR, mass spectrometry (EI-MS and HRMS) and elemental analysi s. S ngle crystal X-ray crystallographic study of trans-1-(4′-methoxyphenyl)-3-methoxy-4-(5 ′-chloro-3′-methyl-1′-phenyl-1H-pyrazol-4′yl)azetidin-2-one 5p has confirmed the molecular structure and the ster eochemical outcome. The cis or trans configuration of β-lactams ( 5, 6) was assigned with respect to position of C3-H and C4-H.

Facile synthesis of novel monocyclic trans- and cis-3-oxo/thio/seleno-4-pyrazolyl-β-lactams