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The construction of a novel series of enantiopure tetrahydrofuranyl 1,2,3-triazolyl C-nucleoside analogues utilizing click reaction of sugar derived tetrahydrofuranyl alkynes with various ‘in house’ synthesized sugar derived tetrahydrofuranyl azides and an adamantyl azide is described. The biological significance of the synthesized C-nucleosides was highlighted by evaluating them in vitro for anti-bacterial and anti-fungal activity, wherein a number of compounds were found to show excellent anti-bacterial activity and moderate anti-fungal activity.

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Stereoselective synthesis of tetrahydrofuranyl 1,2,3-triazolyl C-nucleoside analogues by ‘click’ chemistry and investigation of their biological activity