English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

A new 1,5-diazacyclodecane-based proton sponge 9 has been prepared by treatment of 1,8di(methylamino)naphthalene (7) with 1,8-bis(bromomethyl)naphthalene (8). Though the compound 9 is structurally related both to kinetically low-active 1,8bis(dimethylamino)naphthalene (1, parent proton sponge) and kinetically active 1,8bis(dimethylaminomethyl)naphthalene (2), X-ray and basicity studies have revealed that the proton sponge behavior of the former dominates. It is found that double alkylation of 1dimethylamino-8-methylaminonaphthalene (11) with 8 touches only the NHMe functionality and leads to the substitution of the N–Me group, yielding the previously unknown benz[de]isoquinoline proton sponge 15. The reaction of 8 with 1,8-diaminonaphthalene or 2,2dimethyl-2,3-dihydroperimidine gives, along with other products, proton sponge 18 with two benzisoquinoline fragments.

1,8-Bis(bromomethyl)naphthalene in the synthesis of 1,5-diazacyclodecane and benz[de]isoquinoline proton sponges