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Some new substituted quinolinyl chalcones were synthesized and evaluated for their in vitro antimicrobial activity against Gram positive and Gram negative strains using a microdilution procedure. Synthesized compounds 10a-g and 13h-q prove to be effective with MIC (mg ml), among them 10a, 10b, 10c, 13I, 13p showed excellent activity against a panel of microorganisms. The newly synthesized compounds were characterized using IR, H-NMR and elemental analysis.

Design, synthesis and evaluation of novel quinolinyl chalcones as antibacterial agents