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A series of 1-substituted isochromanes has been synthesized from the corresponding alkyl 2- acylphenylacetates 3, by reduction and cyclization with a catalytic amount of p-toluenesulfonic acid monohydrate (PTSA), as compounds with potential antitumor activity and N-bearing heterocycle analogues.

Application of ortho-acylated phenylacetic acid esters to the synthesis of 1-substituted isochromanes