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Multi component condensation of an aryl aldehyde, acetyl chloride, acetonitrile and enolisable ketone in presence of Nafion-H, as an efficient, environment friendly heterogenous and recyclable catalyst for the one-pot synthesis of β-acetamido ketones in high yields is described.

arkivoc

Perfluorinated resin-sulfonic acid (Nafion-H): an efficient, environment friendly and recyclable heterogeneous catalyst for the one-pot multicomponent synthesis of β-acetamido ketones