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The synthesis of a novel class of potential aspartyl-protease inhibitors is described. Arrays of 1,4,5-trisubstituted 1-(4-piperidyl)-imidazoles have been assembled by parallel synthesis using an isocyanide-based multi component reaction (vL-3CR).

Parallel synthesis of arrays of 1,4,5-trisubstituted 1-(4-piperidyl)-imidazoles by IMCR: A novel class of aspartyl protease inhibitors