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The anthracene-carbohydrate hybrids were designed and synthesized via an effective glycosidation. The hybrids cleaved double stranded DNA at the guanine site upon irradiation with UV light of a long wavelength and without any additive. The anthracene-carbohydrate hybrid system was very effective for the DNA cleavage. Furthermore, the anthracenecarbohydrate hybrids exhibited photoselective and strong cytotoxicity against cancer cells with photoirradiation.

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Molecular design, chemical synthesis, and biological evaluation of anthracene-carbohydrate hybrids as novel DNA photocleaving and photoselective cytotoxic agents