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A comparison is established between the experimental conditions associated with the multistep synthesis of ethyl 1,2,3,4-tetrahydro-6-methyl-2-oxo-4-phenylpyrimidine-5-carboxylate from Merrifield’s resin and soluble polymers, derived from poly(ethylene glycol), poly(styrene-coallyl alcohol), or dendritic aliphatic polyols.

Insoluble versus soluble polymer-assisted synthesis. A first approach for the preparation of a Biginelli compound