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The polymer-supported synthesis of 2,5-disubstituted furans using a traceless linker strategy is described. Deprotonation of a Merrifield resin-bound methyl aryl sulfone followed by reaction with diethyl chlorophosphate furnishes a phosphonate, the lithio-derivative of which reacts in situ with α-methoxyaldehydes to yield vinylsulfones. Base-mediated isomerisation to the allylsulfones followed by reaction of the derived anions with aldehydes gives alcohols; trifluoroacetic acid treatment provides 2,5-disubstituted furans with concomitant cleavage from the solid support.

Sulfone-mediated synthesis of substituted furans on solid support