English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

A number of N-(5,5-dimethyl-2(5H)-thiophenyliden)amines and N-(1-thiaspiro(4.5)dec-3-en-2- yliden)amines, existing exclusively in one isomeric form, have been obtained in good to excellent yields by reaction of lithiated 1,1-disubstituted 1,2-dienes with isothiocyanates followed by treatment with t-BuOH and t-BuOK in DMSO. Investigation of the isomeric structures using 1H, 13C, 15N, 2D NOESY NMR spectroscopy and quantum-chemical calculation (ab initio HF/6-31G*) of the total energies of the fully optimized geometries indicated that for both N-(5,5-dimethyl-2(5H)-thiophenyliden)methanamine and N-(1- thiaspiro(4.5)dec-3-en-2-yliden)methanamine the Z-isomers are more stable, the energy differences with respect to E-isomers being 3.37-3.87 kcal/mol. It was established that the chair conformer with axial orientation of sulfur of (Z)-N-(1-thiaspiro(4.5)dec-3-en-2- yliden)methanamine the has the lowest energy of all possible conformers.

N-[5,5-dimethyl-2(5H)-thiophenyliden]amines and N-(1-thiaspiro[4.5]dec-3-en-2-yliden)amines: Synthesis and isomerism