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4 pages, 2 figures, 1 table.A band of approximately 52-53 kDa, corresponding to glial fibrillary acidic protein (GFAP) was detected by\udimmunoblot techniques in brain tissue of a marine fish (Dentex dentex L). The aim of this study was to quantify the density\udof GFAP during the life cycle of a marine fish in the wild. The levels of GFAP immunoreactivity were determined at two\uddifferent stages of development: juvenile (body weight range: 180-360 g) and sexually developing-mature specimens (body\udweight range: 2329-5550 g) from a natural population in the Western Mediterranean Sea. Our results indicated a negative\udcorrelation between the immunoreactivity of GFAP and weight in the sexually developing-mature group of fishes (r=-0.785,\udp<0.05, n=8). These findings might be of relevance in understanding the role of GFAP in the development of the central\udnervous system and demonstrate that GFAP down-regulation in D. dentex brain tissue during development is a natural physiological\udphenomenon.Peer reviewe

Down-regulation of Glial Fibrillary Acidic Protein (GFAP) during the development of a marine fish (Dentex dentex L.)