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Cochlear damage of the Hamster induced by injection of Kanamycin into the middle ear cavity was studied using SEM.(1) The Changes in theorgan of Corti were apparent in the outer hair cells. The changes in the inner hair cells were slight.(2) The damage of outer hair cells in the basal tum was more severe than those in the middle and apical turn.(3) The damage of 1st. row was the severest in outer hair cells in both the middle turn and the lower portion of the apicel turn.(4) The damage of inner hair cells was more severe in the basal turn and the apical turn.Cochlear damage of the Hamster induced by intramuscuar injection of Kanamycin and protective effect of cepharanthine against the ototoxicity was studied using SEM and ABR.(1) The latency of wave I was almost nochange in ABR.(2) Three animals had the sudden prolongation of wave I latency and the threshold shift. Before the prolongation, wave I latency was slightly shortened.(3) The changes in the organ of Corti were similar to those in the experiment of KM intra middle ear injection.(4) Cochlear damages of in the Hamster administered both Kanamycin and cepharanthine were slight than those administered only Kanamycin in SEM study.(5) Protective effect of cepharanthine against KM induced ototoxicity was recognized.

nippon jibi inkouka gakkai kaihou/nippon jibi inkoka gakkai kaiho

Evaluation of cochlear damage in kanamycin administered hamster and protective effect of cepharanthine against KM induced ototoxicity an experimental study.