English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

A study was made on the influence of Diamox (acetazolamide sodium) upon inner ear tissue and inner ear fluid, for this drug has been in use for glaucoma for its depressive effect upon the intraocular pressure. On an assumption of the presence of carbonic anhydrase in stria vascularis, widely recognized site of secretion of endolymph, histochemical demonstration of the enzyme was also attempted by modified Hausler's method. Materials used were human kidneys and adult normal guinea pigs and rats. Vital transfusion fixative specimen of inner ear of adult normal guinea pigs were made 1, 3, 6, 12 and 24 hours respectively after the injection of 100 mg Kg of acetazolamide sodium. One-hour specimen showed marked dilation of capillaries of stria vascularis and twelve-hour specimen, depression of Reissner's membrane. Decrease of sodium in endolymph was noted one hour after the injection of the substance. When 20 micron thick, non-decalcified frozen section of cochlea, placed on a eolodium menbrane, was free floated on the surface of the incubation medium according to Hausler's method, stria vascularis was positively stained to indicate the presence of carbonic anhydrase. The same method also demonstrated the activity of carbonic anhydrase along the inner border or brush border of urinary tubule endothelia of human kidney as well as in the proximal urinary tubule endothelia of normal adult rat and guinea pig.

INFLUENCE OF DIAMOX (ACETAZOLAMIDE SODIUM) UPON INNER EAR AND HISTOCHEMICAL STUDY OF CARBONIC ANHYDRASE