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To the Editor: We read with interest about the study by Payet, et al investigating prevalence and discriminatory value of anticyclic citrullinated peptide (anti-CCP) antibodies in patients with rheumatic diseases other than rheumatoid arthritis (RA)1. Although several studies have been published aiming to identify the prevalence of anti-CCP in patients with different rheumatic conditions2,3,4, Payet’s study was performed in a very large patient cohort and represents, therefore, a relevant information source on this topic. The overall prevalence of anti-CCP in the 723 non-RA patients was rather high compared to other studies5,6,7, with a very high proportion of patients with connective tissue disease (CTD) with anti-CCP (17.5%). This allowed the conclusion that, although anti-CCP are rather specific for RA, they are consistently expressed in patients with other rheumatic diseases. However, it should be noted that, unlike previously published studies analyzing anti-CCP prevalence in non-RA disorders, the design of Payet’s investigation considered the analysis of … Address correspondence to Prof. R. Gerli, Rheumatology Unit, Department of Medicine, University of Perugia, Via Enrico dal Pozzo snc, I-06122, Perugia, Italy. E-mail: roberto.gerli{at}unipg.it

Anticyclic Citrullinated Peptide Antibodies in Patients with Rheumatic Diseases other than Rheumatoid Arthritis: Clinical or Pathogenic Significance?