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This research explores a contemporary approach to managing Oral Squamous Cell Carcinoma ( OSCC ) by integrating nano-technology into herbal production, combining    Bischofia   javanica    leaves and    Phaleria   macrocarpa    fruits. Benzo[a]pyrene ( BaP )-induced  OSCC  rats were treated with nano herbals from    Bischofia   javanica    leaves,    Phaleria   macrocarpa    fruits, a combination of both, and Vitamin C as a control. Blood and organ analyses were compared with negative and positive controls.  BaP  induction in  OSCC  revealed cell transformation into carcinoma, confirmed by Papanicolaou staining.  OSCC  induction also caused significant changes in Complete Blood Count ( CBC ) and serum lipid profile. Nano herbals from both plants showed potential in reducing hematological and lipid damage in  OSCC , especially in white blood cells, red blood cells, hemoglobin, and platelets. Statistical analysis also indicated that the combination of nano herbals was more effective in reducing (Low-Density Lipoprotein)  LDL  and total cholesterol levels than uncombined use while increasing (High-Density Lipoprotein)  HDL  levels comparable to Vitamin C. Liver and kidney functions were also significantly affected by  OSCC , with nano herbals showing potential in normalizing albumin levels and positively impacting liver enzymes. In conclusion, both individually and in combination, nano herbals from    Bischofia   javanica    leaves, and    Phaleria   macrocarpa    fruits have the potential to be a promising treatment strategy for  OSCC .

pharmacia

﻿   Bischofia   javanica    and    Phaleria   macrocarpa    nano herbal combination on blood and liver-kidney biochemistry in Oral Squamous Cell Carcinoma-induced rats

﻿ Bischofia javanica and Phaleria macrocarpa nano herbal combination on blood and liver-kidney biochemistry in Oral Squamous Cell Carcinoma-induced rats

Bischofia javanica and Phaleria macrocarpa nano herbal combination on blood and liver-kidney biochemistry in Oral Squamous Cell Carcinoma-induced rats