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This study investigates the bioproduction of astragalosides I, II and IV from endemic    Astracantha   aitosensis    ( arnacantha ) and    Astragalus   membranaceus    species, and the biotechnological methods for increased efficiency. The extracts from established  in vitro  cultures, including    A.   aitosensis    callus, shoots and roots and    A.   membranaceus    hairy roots, showed higher astragaloside concentrations than native roots. Specifically,  in vitro    A.   aitosensis    cultures produced astragaloside I and II at 0.06 and 0.10 mg/g DW, which were absent in native roots. The production of    A.   membranaceus   s hairy roots exceeds 8 to 15 times astragaloside I and II (0.80 and 0.90 mg/g DW) production when compared to native roots (0.10 and 0.05 mg/g DW), and around 3 times high amount related to astragaloside IV. Addressing astragaloside production challenges, this research also reveals biotechnology approaches as an alternative for sustainable production of this rare cycloartane saponins, conserving the natural habitats. A pilot reproducible  in vitro  cellular platform has been created, and protocol for specific, unconventional induction of the biosynthesis of the desired target compounds, exploiting the enzymatic system of plant cells from the unexplored plant species    A.   aitosensis    has been established. Our findings clearly show the possibility of using  in vitro  cultures of    A.   aitosensis    and    A.   membranaceus    for biotechnology production of cycloartane type saponins.

pharmacia

﻿Biotechnological approaches for sustainable production of astragaloside I, II and IV from endemic species of    Astracantha   aitosensis    (Ivan.) and    Astragalus   membranaceus    (fisch.) by  in vitro  cultures

﻿Biotechnological approaches for sustainable production of astragaloside I, II and IV from endemic species of Astracantha aitosensis (Ivan.) and Astragalus membranaceus (fisch.) by in vitro cultures

Biotechnological approaches for sustainable production of astragaloside I, II and IV from endemic species of Astracantha aitosensis (Ivan.) and Astragalus membranaceus (fisch.) by in vitro cultures