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In the current study, we investigated the effect of creatine monohydrate ( CrM ) and newly synthesized creatine lysinate ( CrLys ) in tail suspension ( TST ) and rotarod tests and their influence on the histology of the skeletal muscles. In the  TST , a slight decrease in the immobility time from the 1 st  to the 3 rd  week was observed in the group treated with  CrM  at a dose of 1.5 g/kg/day and  CrLys  at a dose of 6 g/kg/day. The rotarod test revealed that  CrM  (1.5 g/kg/day) and  CrLys  (3 g/kg/day) lead to a significant improvement in motor coordination in the 3 rd  week. The results from histology showed an increase in the muscle fiber diameter of soleus muscle in animals treated with  CrM  (3 g/kg/day) and  CrLys  (6 g/kg/day). The results showed that supplementation with creatine derivatives appears to be a generally effective nutritional ergogenic aid for an improvement of physical performance.

Creatine lysinate – part II: effects on the motor coordination and muscle hypertrophy in mice