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Morinda   citrifolia    fruit (Noni) has been used as a folk medicine in several countries. Noni possessed various pharmacological activities such as; anticancer, antidiabetic, antihypertensive, antarthritic, and antioxidants. The present study evaluated pharmacognostic properties, profiling of active constituent through High-Performance Thin Layer Chromatography ( HPTLC ) and Liquid Chromatography-High Resolution Mass Spectrometer ( LC-HRMS ) run for quantitative and qualitative phytochemical analysis and determining angiotensin-converting enzyme ( ACE ) inhibitor activity of Noni from three different locations. The physicochemical parameters of crude drugs and extracts met the requirement of Indonesian Herbal Pharmacopeia. Total phenol content was 2.16-3.08 mg  GAE /g extract and total flavonoid content was 0.11 - 1.58 mg  QE /g extract.  HPTLC  analysis revealed that scopoletin content in Noni was in the range of 0.44 - 0.51%. The results were also corresponding well with  LC-HRMS  fingerprint analysis. In addition, Noni fruit extract from Bogor potential exhibited activity in inhibiting  ACE  with an IC50 value of 206.26 µg/mL.

pharmacia

﻿Quality control standardization of Indonesian noni fruit (   Morinda   citrifolia   ) extract and evaluation of their angiotensin-converting enzyme inhibitory activity

﻿Quality control standardization of Indonesian noni fruit ( Morinda citrifolia ) extract and evaluation of their angiotensin-converting enzyme inhibitory activity

Quality control standardization of Indonesian noni fruit ( Morinda citrifolia ) extract and evaluation of their angiotensin-converting enzyme inhibitory activity